In these challenging times, medical research has never been more important. The wellbeing of billions of people across the world depends upon continual medical advances across all areas of health. The Medical Research Foundation is dedicated to advancing medical research, improving human health and changing people’s lives. Free to choose its own research priorities, the charity is responsive and flexible in the way it allocates funding. Current research priorities, identified based on gaps in understanding, are the threat of drug resistant infections, adolescent mental health, and pain research. These are key public health challenges requiring ground-breaking ideas from some of the UK’s leading scientists. The Foundation would like to fund even more outstanding researchers and can only do this with your support. A gift of any size will directly fund medical research that could make a lasting difference to human health for decades to come.